
30 SECONDS OF THERAPY: Lower Extremity in Hypermobility Spectrum Disorder (HSD) and Ehlers-Danlos Syndrome (EDS)
May 12
9 min read
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START
Screen for subluxations and asymmetries
HSD/EDS is a rare connective tissue disorder that causes joint hypermobility, subluxations, instability, pain.
Standing and seated flexion tests for sacral and ilium torsions
Marching test/Gillet test (sensitivity 43%) for sacral excessive mobility
Palpation for guarded piriformis, iliopsoas, pubis indicating joint instability.
Lower Limb Assessment Score for hypermobility patterns (e.g., knee hyperextension >3 cm, subtalar inversion >45°, MTP DF >90°)
USe the download assessment on our website and (https://www.ehlers-danlos.com/assessing-joint-hypermobility/)
Incorporate long-hold techniques and muscle energy, since hypermobile joints need stabilization before mobilization.
Long-hold joint glides (90 sec) to reduce autonomic tone and guarding.
Muscle energy techniques (MET) using agonist contraction e.g., hamstrings for anteriorly rotated ileum, iliopsoas for sacral torsion.
Positional release for sharp, bruised pain at tender points.
Start teaching self-correction and movement strategies to empower patients with simple home tools.
Anterior hip subluxation: ankle-on-knee MET with resisted abduction.
Upslip: quick pull “sneeze” method (avoid if anterior impingement)
Talus anterior subluxation: strap-pull DF correction against wall or opposite foot.
STOP
Stop over mobilizing lax structures, as patients with HSD/EDS often experience joint instability, not stiffness
Avoid Grade V mobilizations in unstable segments.
Prefer long-hold MFR or gentle glides for autonomic-driven tone.
Overmobilization can increase pain sensitization and fear of movement.
Progressing patients based on time alone.
Posterior hip subluxation: avoid deep squats, leg press, sit-to-stand initially.
Anterior hip subluxation: avoid straight leg raises in supine without cuing for glute contraction.
Initially avoid excessive use of gluteal muscles. Strengthen the hip flexor and abdominals. Start gluteal work in protected positions — Have the hip in extension and possibly ER.
Stop Ignoring the kinetic chain, as even minor misalignments can impact the whole body.
A posteriorly displaced fibula can mimic medial knee pain.
Anterior talus subluxation limits DF and alters knee and hip mechanics.
Realign the pelvis, hip, tib/fib, and foot before loading.
WHY
Why Do Lower Extremity Issues in HSD/EDS Cascade?
Joint instability is not isolated. A single subluxation (e.g., anterior hip) alters biomechanics up and down the chain—from the pelvis to the foot—leading to secondary pain and motor guarding in surrounding joints.
Why Prioritize Stabilization Before Mobilization?
References: MedBridge Lower Extremity Presentation in HSD/EDS Heather Purdin, MSPT, CMPT Patricia Stott, PT, DPT, ATC, CHT, CYT Akhtar, M. A., & Keating, J. F. (2010). Meniscal injuries and hyperlaxity. British Journal of Sports Medicine, 44(14), i1–i1. https://doi.org/10.1136/bjsm.2010.078972.3 Ali, A., Andrzejowski, P., Kanakaris, N. K., & Giannoudis, P. V. (2020). Pelvic girdle pain, hypermobility spectrum disorder and hypermobility-type Ehlers-Danlos Syndrome: A narrative literature review. Journal of Clinical Medicine, 9(12), 3992. https://doi.org/10.3390/jcm9123992 Beel, W., Macchiarola, L., Mouton, C., Laver, L., & Seil, R. (2022). The hypermobile and unstable lateral meniscus: A narrative review of the anatomy, biomechanics, diagnosis and treatment options. Annals of Joint, 7, 14–14. https://doi.org/10.21037/aoj-21-9 Berglund, B., Nordström, G., Hagberg, C., & Mattiasson, A. C. (2005). Foot pain and disability in individuals with Ehlers–Danlos syndrome (EDS): Impact on daily life activities. Disability and Rehabilitation, 27(4), 164–169. https://doi.org/10.1080/09638280400009352 Biernacki, J. L., Stracciolini, A., Fraser, J., Micheli, L. J., & Sugimoto, D. (2021). Risk factors for lower-extremity injuries in female ballet dancers: A systematic review. Clinical Journal of Sport Medicine, 31(2), e64–e79. https://doi.org/10.1097/jsm.0000000000000707 Brown, C. L., Rizer, M., Alexander, R., Sharpe, E. E., III, & Rochon, P. J. (2018). Pelvic congestion syndrome: Systematic review of treatment success. Seminars in Interventional Radiology, 35(1), 35–40. https://doi.org/10.1055/s-0038-1636519 Camerota, F., Galli, M., Cimolin, V., Celletti, C., Ancillao, A., Blow, D., & Albertini, G. (2015). The effects of neuromuscular taping on gait walking strategy in a patient with joint hypermobility syndrome/Ehlers–Danlos syndrome hypermobility type. Therapeutic Advances in Musculoskeletal Disease, 7(1), 3–10. https://doi.org/10.1177%2F1759720X14564561 Corrado, B., & Ciardi, G. (2018). Hypermobile Ehlers-Danlos syndrome and rehabilitation: Taking stock of evidence based medicine: A systematic review of the literature. Journal of Physical Therapy Science, 30(6), 843–847. https://doi.org/10.1589/jpts.30.847 D’Ambrogio, K. J., & Roth, G. B. (1997). Positional release therapy: Assessment and treatment of musculoskeletal dysfunction. Mosby. Davies, C. (2004). The trigger point therapy workbook. New Harbinger Publications. Devitt, B. M., Smith, B. N., Stapf, R., Tacey, M., & O’Donnell, J. M. (2017). Generalized joint hypermobility is predictive of hip capsular thickness. Orthopaedic Journal of Sports Medicine, 5(4), 2325967117701882. https://doi.org/10.1177/2325967117701882 Dreyfuss, P., Michaelsen, M., Pauza, K., McLarty, J., & Bogduk, N. (1996). The value of medical history and physical examination in diagnosing sacroiliac joint pain. Spine, 21(22), 2594– 2602. https://doi.org/10.1097/00007632-199611150-00009 Dydyk, A. M., Forro, S. D., & Hanna, A. (2023, January 15). Sacroiliac joint injury. In StatPearls. StatPearls Publishing. Retrieved February 22, 2023, from https://www.ncbi.nlm.nih.gov/books/NBK557881/ Engelbert, R. H., Juul-Kristensen, B., Pacey, V., de Wandele, I., Smeenk, S., Woinarosky, N., Sabo, S., Scheper, M. C., Russek, L., & Simmonds, J. V. (2017). The evidence-based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome/hypermobile Ehlers Danlos syndrome. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 175(1), 158–167. https://doi.org/10.1002/ajmg.c.31545 Enix, D. E., & Mayer, J. M. (2019). Sacroiliac joint hypermobility biomechanics and what it means for health care providers and patients. PM&R, 11(S1), S32–S39. https://doi.org/10.1002/pmrj.12176 Esfandiarpour, F., Lebrun, C. M., Dhillon, S., & Boulanger, P. (2018). In-vivo patellar tracking in individuals with patellofemoral pain and healthy individuals. Journal of Orthopaedic Research, 36(8), 2193–2201. https://doi.org/10.1002/jor.23887 Gibbons, J. (2022). Muscle energy techniques, second edition: A practical guide for physical therapists. North Atlantic Books. Golightly, Y. M., Hannan, M. T., Nelson, A. E., Hillstrom, H. J., Cleveland, R. J., Kraus, V. B., Schwartz, T. A., Goode, A. P., Flowers, P., Renner, J. B., & Jordan, J. M. (2019). Relationship of joint hypermobility with ankle and foot radiographic osteoarthritis and symptoms in a community-based cohort. Arthritis Care & Research, 71(4), 538–544. https://doi.org/10.1002/acr.23686 Guier, C., Shi, G., Ledford, C., Taunton, M., Heckman, M., & Wilke, B. (2020). Primary total hip arthroplasty in patients with Ehlers-Danlos syndrome: A retrospective matched-cohort study. Arthroplasty Today, 6(3), 386–389. https://doi.org/10.1016/j.artd.2020.05.006 Hanna, T., Smith, N. P., & Sebastianelli, W. J. (2022). Treatment, return to play, and performance following meniscus surgery. Current Reviews in Musculoskeletal Medicine, 15(3), 157– 169. https://doi.org/10.1007/s12178-022-09754-7 Hiemstra, L. A., Kerslake, S., Kupfer, N., & Lafave, M. R. (2019). Generalized joint hypermobility does not influence clinical outcomes following isolated MPFL reconstruction for patellofemoral instability. Knee Surgery, Sports Traumatology, Arthroscopy, 27(11), 3660– 3667. https://doi.org/10.1007/s00167-019-05489-0 Johannsen, A. M., Ejnisman, L., Behn, A. W., Shibata, K., Thio, T., & Safran, M. R. (2019). Contributions of the capsule and labrum to hip mechanics in the context of hip microinstability. Orthopaedic Journal of Sports Medicine, 7(12), 2325967119890846. https://doi.org/10.1177/2325967119890846 Junge, T., Henriksen, P., Hansen, S., Østengaard, L., Golightly, Y. M., & Juul‐Kristensen, B. (2019). Generalised joint hypermobility and knee joint hypermobility: Prevalence, knee joint symptoms and health‐related quality of life in a Danish adult population. International Journal of Rheumatic Diseases, 22(2), 288–296. https://doi.org/10.1111/1756- 185x.13205 Junge, T., Larsen, L. R., Juul-Kristensen, B., & Wedderkopp, N. (2015). The extent and risk of knee injuries in children aged 9–14 with generalised joint hypermobility and knee joint hypermobility - The CHAMPS-study Denmark. BMC Musculoskeletal Disorders, 16(1), Article 143. https://doi.org/10.1186/s12891-015-0611-5 Kamanli, A., Sahin, S., Ozgocmen, S., Kavuncu, V., & Ardicoglu, O. (2004). Relationship between foot angles and hypermobility scores and assessment of foot types in hypermobile individuals. Foot & Ankle International, 25(2), 101–106. https://doi.org/10.1177/107110070402500211 Koch, M., Memmel, C., Zeman, F., Pfeifer, C. G., Zellner, J., Angele, P., Weber-Spickschen, S., Alt, V., & Krutsch, W. (2020). Early functional rehabilitation after meniscus surgery: Are currently used orthopedic rehabilitation standards up to date? Rehabilitation Research and Practice, 2020, 1–8. https://doi.org/10.1155/2020/3989535 Kraeutler, M. J., Garabekyan, T., Pascual-Garrido, C., & Mei-Dan, O. (2016a). Hip instability: A review of hip dysplasia and other contributing factors. Muscles, Ligaments and Tendons Journal, 6(3), 343–353. https://doi.org/10.11138/mltj/2016.6.3.343 Kraeutler, M. J., Garabekyan, T., Pascual-Garrido, C., & Mei-Dan, O. (2016b). Ligamentum teres tendinopathy and tears. Muscles, Ligaments and Tendons Journal, 6(3), 337–342. https://doi.org/10.11138/mltj/2016.6.3.337 Levangie, P. K. (1999). Four clinical tests of sacroiliac joint dysfunction: The association of test results with innominate torsion among patients with and without low back pain. Physical Therapy, 79(11), 1043–1057. Malfait, F., Francomano, C., Byers, P., Belmont, J., Berglund, B., Black, J., Bloom, L., Bowen, J. M., Brady, A. F., Burrows, N. P., Castori, M., Cohen, H., Colombi, M., Demirdas, S., De Backer, J., De Paepe, A., Fournel-Gigleux, S., Frank, M., Ghali, N., . . . Tinkle, B. (2017). The 2017 international classification of the Ehlers-Danlos syndromes. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 175(1), 8–26. https://doi.org/10.1002/ajmg.c.31552 Meyer, K. J., Chan, C., Hopper, L., & Nicholson, L. L. (2017). Identifying lower limb specific and generalised joint hypermobility in adults: Validation of the Lower Limb Assessment Score. BMC Musculoskeletal Disorders, 18(1), 1–9. https://doi.org/10.1186/s12891-017- 1875-8 Minhas, D. (2021). Practical management strategies for benign hypermobility syndromes. Current Opinion in Rheumatology, 33(3), 249–254. https://doi.org/10.1097/bor.0000000000000798 Nee, J., Kilaru, S., Kelley, J., Oza, S. S., Hirsch, W., Ballou, S., Lembo, A., & Wolf, J. (2019). Prevalence of functional GI diseases and pelvic floor symptoms in Marfan syndrome and Ehlers-Danlos syndrome: A national cohort study. Journal of Clinical Gastroenterology, 53(9), 653–659. https://doi.org/10.1097/MCG.0000000000001173 Nicholson, L. L., Simmonds, J., Pacey, V., De Wandele, I., Rombaut, L., Williams, C. M., & Chan, C. (2022). International perspectives on joint hypermobility: A synthesis of current science to guide clinical and research directions. Journal of Clinical Rheumatology, 28(6), 314– 320. https://doi.org/10.1097/rhu.0000000000001864 Pacey, V., Nicholson, L. L., Adams, R. D., Munn, J., & Munns, C. F. (2010). Generalized joint hypermobility and risk of lower limb joint injury during sport: A systematic review with meta-analysis. The American Journal of Sports Medicine, 38(7), 1487–1497. https://doi.org/10.1177/0363546510364838 Pacey, V., Tofts, L., Adams, R. D., Munns, C. F., & Nicholson, L. L. (2013). Exercise in children with joint hypermobility syndrome and knee pain: A randomised controlled trial comparing exercise into hypermobile versus neutral knee extension. Pediatric Rheumatology, 11(1). https://doi.org/10.1186/1546-0096-11-30 Palmer, S., Bailey, S., Barker, L., Barney, L., & Elliott, A. (2014). The effectiveness of therapeutic exercise for joint hypermobility syndrome: A systematic review. Physiotherapy, 100(3), 220–227. https://doi.org/10.1016/j.physio.2013.09.002 Palomo-Toucedo, I. C., Vázquez-Bautista, C., Munuera-Martínez, P. V., Domínguez-Maldonado, G., Castillo-López, J. M., & Reina-Bueno, M. (2020). Podiatry alterations in Ehlers-Danlos syndrome. Medicina Clínica (English Edition), 154(3), 94–97. https://doi.org/10.1016/j.medcle.2019.05.009 Peterson, B., Coda, A., Pacey, V., & Hawke, F. (2018). Physical and mechanical therapies for lower limb symptoms in children with hypermobility spectrum disorder and hypermobile Ehlers-Danlos Syndrome: A systematic review. Journal of Foot and Ankle Research, 11(1). https://doi.org/10.1186/s13047-018-0302-1 Reina-Bueno, M., Vázquez-Bautista, C., Palomo-Toucedo, I. C., Domínguez-Maldonado, G., Castillo-López, J. M., & Munuera-Martínez, P. V. (2020). Custom-made foot orthoses reduce pain and fatigue in patients with Ehlers-Danlos syndrome. A pilot study. International Journal of Environmental Research and Public Health, 17(4), 1359. https://doi.org/10.3390/ijerph17041359 Reychler, G., De Backer, M. M., Piraux, E., Poncin, W., & Caty, G. (2021). Physical therapy treatment of hypermobile Ehlers–Danlos syndrome: A systematic review. American Journal of Medical Genetics Part A, 185(10), 2986–2994. https://doi.org/10.1002/ajmg.a.62393 Robbins, S. M., Cossette‐Levasseur, M., Kikuchi, K., Sarjeant, J., Shiu, Y. G., Azar, C., & Hazel, E. M. (2020). Neuromuscular activation differences during gait in patients with Ehlers‐ Danlos syndrome and healthy adults. Arthritis Care & Research, 72(11), 1653–1662. https://doi.org/10.1002/acr.24067 Rombaut, L., Malfait, F., De Wandele, I., Thijs, Y., Palmans, T., De Paepe, A., & Calders, P. (2011). Balance, gait, falls, and fear of falling in women with the hypermobility type of EhlersDanlos syndrome. Arthritis Care & Research, 63(10), 1432–1439. https://doi.org/10.1002/acr.20557 Saueressig, T., Owen, P. J., Diemer, F., Zebisch, J., & Belavy, D. L. (2021). Diagnostic accuracy of clusters of pain provocation tests for detecting sacroiliac joint pain: Systematic review with meta-analysis. Journal of Orthopaedic & Sports Physical Therapy, 51(9), 422–431. https://doi.org/10.2519/jospt.2021.10469 Smith, T. O., Bacon, H., Jerman, E., Easton, V., Armon, K., Poland, F., & Macgregor, A. J. (2013). Physiotherapy and occupational therapy interventions for people with benign joint hypermobility syndrome: A systematic review of clinical trials. Disability and Rehabilitation, 36(10), 797–803. https://doi.org/10.3109/09638288.2013.819388 Smith, T. O., Jerman, E., Easton, V., Bacon, H., Armon, K., Poland, F., & Macgregor, A. J. (2013). Do people with benign joint hypermobility syndrome (BJHS) have reduced joint proprioception? A systematic review and meta-analysis. Rheumatology International, 33(11), 2709–2716. https://doi.org/10.1007/s00296-013-2790-4 Stern, C. M., Pepin, M. J., Stoler, J. M., Kramer, D. E., Spencer, S. A., & Stein, C. J. (2017). Musculoskeletal conditions in a pediatric population with Ehlers-Danlos syndrome. The Journal of Pediatrics, 181, 261–266. https://doi.org/10.1016/j.jpeds.2016.10.078 Tibbo, M. E., Wyles, C. C., Houdek, M. T., & Wilke, B. K. (2019). Outcomes of primary total knee arthroplasty in patients with Ehlers-Danlos syndromes. The Journal of Arthroplasty, 34(2), 315–318. https://doi.org/10.1016/j.arth.2018.09.079 Tinkle, B., Castori, M., Berglund, B., Cohen, H., Grahame, R., Kazkaz, H., & Levy, H. (2017). Hypermobile Ehlers-Danlos syndrome (a.k.a. Ehlers-Danlos syndrome Type III and Ehlers-Danlos syndrome hypermobility type): Clinical description and natural history. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 175(1), 48– 69. https://doi.org/10.1002/ajmg.c.31538 To, M., & Alexander, C. M. (2019). Are people with joint hypermobility syndrome slow to strengthen? Archives of Physical Medicine and Rehabilitation, 100(7), 1243–1250. https://doi.org/10.1016/j.apmr.2018.11.021 Tsai, C. C., Chih, Y. C., Shih, C. L., Chen, S. J., Shen, P. C., & Tien, Y. C. (2022). Joint hypermobility and preschool-age flexible flatfoot. Medicine, 101(31). https://doi.org/10.1097%2FMD.0000000000029608 van Dijk, F. S., Ghali, N., Demirdas, S., & Baker, D. (2022, September 15). TNXB-related classicallike Ehlers-Danlos syndrome. In M. P. Adam, G. M. Mirzaa, R. A. Pagon, et al. (Eds.), GeneReviews. University of Washington. https://www.ncbi.nlm.nih.gov/books/NBK584019/ van Reijn-Baggen, D. A., Han-Geurts, I. J. M., Voorham-van der Zalm, P. J., Pelger, R. C. M., Hagenaars-van Miert, C. H. A. C., & Laan, E. T. M. (2022). Pelvic floor physical therapy for pelvic floor hypertonicity: A systematic review of treatment efficacy. Sexual Medicine Reviews, 10(2), 209–230. https://doi.org/10.1016/j.sxmr.2021.03.002 Willy, R. W., Hoglund, L. T., Barton, C. J., Bolgla, L. A., Scalzitti, D. A., Logerstedt, D. S., Lynch, A. D., Snyder-Mackler, L., & McDonough, C. M. (2019). Patellofemoral pain. Journal of Orthopaedic & Sports Physical Therapy, 49(9), CPG1–CPG95. https://doi.org/10.2519/jospt.2019.0302 Wong, S. E., Cogan, C. J., & Zhang, A. L. (2022). Physical examination of the hip: Assessment of femoroacetabular impingement, labral pathology, and microinstability. Current Reviews in Musculoskeletal Medicine, 15(2), 38–52. https://doi.org/10.1007/s12178-022-09745-8 |